Colossal Biosciences unveils AI platform GenoMorph to accelerate dodo de-extinction

On October 14, Colossal Biosciences announced the launch of GenoMorph, an AI platform designed to accelerate its de-extinction research. The system integrates 3D morphology, comparative genomics, and developmental biology to identify editable genes even when genetic data is scarce.

GenoMorph is currently being used in the company's effort to revive the dodo, a project constrained by the availability of only one complete dodo genome. By contrast, Colossal has obtained around 100 genomes for its woolly mammoth project, thanks to better DNA preservation in cold climates.

To build the platform, the team gathered developmental data from chickens, quail, ducks, and pigeons, combined with genetic information and 3D skull measurements from more than 70 bird species, over more than a year. The AI learns which DNA regions are active as birds develop beaks and facial structures, helping predict the genetic switches behind the dodo's distinctive appearance. CEO Ben Lamm described the platform as a "treasure map for the dodo genome."

So far, the company has identified approximately 2,300 potential DNA editing targets related to dodo cranial-facial morphology, which will now be tested in the lab. Colossal also announced a new system using lipid nanoparticles to deliver gene-editing tools directly into developing bird embryos, enabling researchers to observe the effects of genetic changes without waiting for a full breeding cycle. In addition, its Nicobar pigeon colony now includes 36 birds, and the team has successfully created the essential cells that become eggs and sperm.